Strategies and Methodologies for Identifying Molecular Targets in Sarcomas and Other Tumors Vinod Ravi, MD and Michael K. K. Wong, MD, PhD, FRCPC Current Treatment Options in Oncology 2005, 6:487-497 Current Science, Inc. ISSN 1527-2729 Copyright © 2005 by Current Science, Inc. Opinion Statement Sarcomas are a heterogeneous group of tumors that respond poorly to conventional cytotoxic chemotherapy. Sarcomas possess specific molecular characteristics that exist because of unique somatic mutations, vital growth factor or growth factor receptor overexpression, or are critically dependent on host pathways. Currently these tumors are classified on the basis of their tissue of origin and histologic appearance. Gene expression and proteomic analysis of sarcomas may enable reclassification of these tumors and help predict their biologic behavior and devise common therapeutic strategies within a class. It may not be long before cDNA/protein expression profiling and karyotyping complement t...